The study conducted in three centers in Israel and Italy examined 604 hospitalized patients with uncomplicated i.e. afebrile and hemodynamically stable for at least 48 hours, gram-negative bacteremia (mostly Enterobacteriaceae). The patients were randomized to antibiotic treatment for 7 days and 14 days.
The primary outcome – composite of all-cause mortality; relapse, suppurative or distant complications and re-admission or extended hospitalization (>14 days) – rates were comparable in the two groups; 46 in the 7 days group vs 48.3% in the 14 days group suggesting that the 7-day course of antibiotic was non-inferior to the longer course.
Hence, patients who respond to the antibiotic may be given a 7-day treatment instead of 14 days.
(Reference: Yahav D, et al. Seven versus fourteen days of antibiotic therapy for uncomplicated gram-negative bacteremia: a non-inferiority randomized controlled trial. Clin Infect Dis. 2018 Dec 11. doi: 10.1093/cid/ciy1054. Epub ahead of print)
Dr KK Aggarwal , Padma Shri Awardee
President Elect Confederation of Medical Associations in Asia and Oceania (CMAAO)